William Dafoe Jr. (d. 22 Haziran, 1955, Wisconsin) bir Akademi Ödülü adayı Amerikalı sinema ve tiyatro oyuncusu. Kariyerinde The Last Temptation of Christ (1988), Örümcek Adam film serisi (2002-2007) ve Platoon (1986) gibi kaliteli filmlerde oynamıştır.

• Heaven's Gate (1980)
• The Loveless (1982)
• The Hunger (1983)
• New York Nights (1984)
• Streets of Fire (1984)
• Roadhouse 66 (1984)
• To Live and Die in L.A. (1985)
• Platoon (1986)
• Off Limits (1988)
• Arrive Alive (1988)
• The Last Temptation of Christ (1988)
• Mississippi Burning (1988)
• Triumph of the Spirit
• Born on the Fourth of July (1989)
• Cry Baby (1990)
• Wild at Heart (1990)
• Flight of the Intruder
• White Sands (1992)
• Light Sleeper (1993)
• Body of Evidence (1993)
• In weiter Ferne, so nah! (1993)
• Clear and Present Danger (1994)
• The Night and the Moment (1995)
• Victory
• Basquiat (1996)
• The English Patient (film) (1996)
• Speed 2: Cruise Control (1997)
• Affliction (1997)
• Lulu on the Bridge
• New Rose Hotel (1998)
• eXistenZ (1999)
• The Boondock Saints (1999)
• American Psycho (2000)
• Animal Factory .... Earl Copen
• Shadow of the Vampire (2000)
• Pavilion of Women
• Edges of the Lord (2000)
• Bullfighter
• Spider-Man (2002)
• Auto Focus (2002)
• Finding Nemo (2003)
• The Reckoning (2003)
• Once Upon a Time in Mexico (2003)
• Control (2004 Direct-to-video movie)
• The Clearing (2004)
• The Aviator (2004)
• Spider-Man 2 (2004)
• Mr. Ripley's Return (2004)
• The Life Aquatic with Steve Zissou (2004)
• XXX: State of the Union (2005)
• Manderlay (2005)
• Before it Had a Name (2005)
• American Dreamz (2006)
• Inside Man (2006)
• Mr. Bean's Holiday (2007)
• Spider-Man 3 (2007)
• Anamorph (2007)
• The Walker (2007)

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